Scientists are working on a gene-hacking drug that could treat baldness

September 15, 2022

Using gene modification techniques, a team of researchers has come up with a new treatment for balding, Wired reports — a condition experienced to varying degrees by two-thirds of American men by age 35.

The team members—associated with the University of California-Irvine and a biotech company called Amplifica—believe they’ve identified the signaling pathway that drives hair growth to find new ways to stop stem cells from giving up on producing hair follicles.

Experiments with mice—as detailed in a new paper published in the journal Developmental Cel l last month—have been promising. The mice were genetically modified to have the hair growth signaling pathway turned on permanently.

The result, according to a report in Futurism:The mice rapidly grew hair, in a promising first step towards a potentially groundbreaking treatment for an incredibly common condition—especially considering that current treatment options like hair transplants and hair growth drugs are invasive and expensive.

Using RNA sequencing, the team found that a molecule called SCUBE3, which appears to hack follicles into producing hair again, was being expressed by the mice that had their genes modified.

In an especially promising twist, the technique even worked in mice that had human hair follicles grafted to their skins.

There’s much work to do before the treatment could be used on people. But UCLA professor and Amplifica chief scientific officer Maksim Plikus has no problems envisioning a future in which SCUBE3 is a simple, Botox injection-like treatment for balding patients.

“You have a patient sitting in a dentist-like chair, they close their eyes, and then you go tch, tch, tch, tch,” Plikus told Wired.

The molecule would simply be injected into the scalp less than a millimeter into the skin, a procedure that would take less than 20 minutes, according to Plikus.

The system does have one major flaw: what if patients don’t have hair follicles to begin with? In that case, they’ll be stuck with the option of having new follicles transplanted.

Despite that limitation, scientists are investigating new ways of addressing an issue faced by the majority of the male population—and a large chunk of the female population as well—with options that are far less invasive and potentially much cheaper.

Research contact: @futurism

March 24, 2023

The world’s top alien hunter is about to embark on his most ambitious—and potentially, historical—mission yet, reports The Daily Beast.

Harvard physicist Avi Loeb is organizing a $1.5-million expedition to Papua New Guinea to search for fragments of a very strange meteorite that impacted just off the coast of the Pacific nation in 2014.

There is compelling evidence that the half-meter-wide meteorite, called CNEOS1 2014-01-08, traveled from outside our solar system. And that it’s made of extremely hard rock or metal—a material that’s hard and tough enough to prove the meteorite isn’t a meteorite at all. Maybe it’s an alien probe.

It’s a long-shot effort. After years of work, Loeb and his team have, with a big assist from the U.S. military, narrowed down CNEOS1 2014-01-08’s likely impact zone to a square kilometer of the ocean floor, nearly two kilometers underwater. But the fragments themselves are probably just a few millimeters in size. It’s worse than looking for a needle in a haystack. Loeb is basically preparing to look for big sand in a square-kilometer patch of small sand.

It’s worth the risk, Loeb told The Daily Beast. Any fragments the team recovers could turn out to be “technological”—that is, clearly manufactured and thus strong evidence of the existence of aliens. Or maybe they’re not artificial, but are made of some super-strong material that we’ve never observed until now. A rare metal forged in the hearts of neutron stars, for example.

In any event, “we will learn something new,” Loeb said.

The expedition is almost ready to depart for Papua New Guinea. “We have a boat,” Loeb wrote in on a post on Medium on January 27. “We have a dream team, including some of the most experienced and qualified professionals in ocean expeditions. We have complete design and manufacturing plans for the required sled, magnets, collection nets and mass spectrometer.

“And most importantly,” he wrote, “today we received the green light to go ahead,” referring to the approval of Papua New Guinea’s for the mission.

The plan, Loeb said, is to deploy a variety of custom sand-sifters—some with magnets, others like huge sieves—and methodically search the seafloor for two weeks. The main reason it’s taken eight years to organize the mission is that, first, Loeb and his team had to figure out where the meteorite’s fragments came down to Earth.

It was easier said than done, since no single instrument precisely captured CNEOS1 2014-01-08’s journey to the seafloor. But if anyone was motivated to try, it was Loeb. While these days more and more scientists are coming around to the idea that we’re probably not alone in the universe, Loeb was banging that drum even when it was unpopular.

When a very odd, shiny, football-field-size object streaked across then out of the solar system in 2017, Loeb was among the first scientists to say out loud what others may only have been thinking: This object, which scientists later named ’Oumuamua ( Hawaiian for “scout”), might be an alien probe.

And Loeb isn’t afraid to put his money—well, his donors’ money—where his mouth is. In addition to studying strange interstellar objects such as ’Oumuamua, Loeb through his Galileo Project is painstakingly building humanity’s first global network of small telescopes , which will scan the sky for alien craft, or at least the remains of alien craft.

To narrow down CNEOS1 2014-01-08’s impact zone, Loeb needed data from two sets of instruments. The first set was from U.S. military missile-warning satellites that, thanks to their sensitive infrared sensors, tend to also detect meteorites while scanning for missile-launches.

These satellites can not only provide at least a vague indication of where a meteorite is heading; they also capture images of the fireball that results from a meteorite’s fast, hot trip through Earth’s atmosphere. The timing and intensity of a fireball can tell us a lot about a meteorite’s composition. Basically, the longer it takes for the atmosphere to ignite a meteor, the tougher the meteor is.

After much wheedling, Loeb convinced the Pentagon to release the full fireball data for CNEOS1 2014-01-08. They indicated the 2014 meteorite might be the hardest meteorite on record.

The second set of data Loeb needed was much more precise telemetry for the meteorite’s path than the military could provide. So, he checked on nearby earthquake sensors. “We found that the blast wave from the meteor explosion generated a high-quality signal in a seismometer located at Manus Island,” which is part of Papua New Guinea, Loeb wrote at Medium.

Armed with the two data sets, Loeb and his team were able to narrow the likely impact zone from 100 square kilometers to just one square kilometer. “This reduction in the geographic uncertainty of the … fireball improves the search efficiency in the forthcoming ocean expedition to recover its fragments,” Loeb and company wrote in a study, not yet peer-reviewed, that appeared online on March 13.

After having arranged funding and manpower, narrowing the search zone, and getting the Papua New Guinean government’s approval, Loeb and his team are now putting the finishing touches on their special sand-sifting equipment for recovering magnetic meteoritic debris from the seafloor.

Once it’s all ready, hopefully this summer, Loeb and his team will set sail.

Expectations are running high. But Loeb said he’s bracing for disappointment. “There is a chance it will fail,” he said of his expedition. Even success could be something of a letdown, if the team recovers fragments, but those fragments turn out to be natural in origin rather than artificial.

It’s important to frame even that secondary discovery as a major advancement, Ravi Kopparapu, an astronomer at NASA’s Goddard Space Flight Center in Maryland, told The Daily Beast. “This could give us more confidence on the nature of the interstellar meteor—and could point to whether this meteor is unique or a new class of meteorites.”

Maybe Loeb and his team will go to all that trouble to find the remains of CNEOS1 2014-01-08, only to confirm it isn’t an alien probe. But don’t expect a setback like that to cause Loeb to give up his search for evidence of extraterrestrials. He said he understands how convincing the proof needs to be, and how hard it might be to find it. “Extraordinary claims require extraordinary evidence,” he said.

Research contact: @thedailybeast