OTC painkillers including Ibuprofen may worsen inflammation, new study shows

January 13, 2023

At the first sign of pain, most of us don’t think twice about cracking open a bottle of ibuprofen, or a similar over-the-counter (OTC) medicine. After all, they’re commonly referred to as painkillers—as in, they are meant to relieve a variety of aches and pains including “headaches, sore muscles, [and] arthritis,” per the National Institutes of Health (NIH).

However, you might want to reconsider reaching for these meds. A new study says that OTC painkillers—including ibuprofen—may actually worsen inflammation, reports Best Life.

What’s more, in a 2022 survey of 2,000 U.S. adults conducted by OnePoll on behalf of Chirp, a company that manufacturers devices for back pain relief, 42% of respondents said they use OTC meds to try to avoid pain altogether. And when they are in pain, 34% of respondents reach for OTC medication.

Many of them reported taking OTC medications regularly. Twenty percent of respondents said they take pain relievers at least once a day, and 12% admitted to taking them “a few times a day.” But now, new research is shining a light on how this practice could be problematic.

The study—presented at the 2022 Radiological Society of North America (RSNA) conference last November—found that taking non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen for osteoarthritis may worsen inflammation in certain cases.

The study looked at 277 participants from the Osteoarthritis Initiative cohort with moderate to severe osteoarthritis of the knee who used NSAID treatment for at least one year, a press release explained.

For these patients, researchers looked at the link between the use of NSAIDs and synovitis, which is “the inflammation of the membrane lining the joint,” Johanna Luitjens, MD, the study’s lead author and a postdoctoral scholar in the Department of Radiology and Biomedical Imaging at the University of California-San Francisco, said in a statement. But the findings weren’t exactly promising.

“In this study, no structural long-term benefit of NSAID use in patients with [osteoarthritis] could be found,” the researchers concluded. “Furthermore, users showed more synovitis at baseline and change over four years, which may lead to an increase in pain and a decrease in joint function.”

Osteoarthritis is the “most common form of arthritis” and is sometimes referred to as “degenerative joint disease,” according to the Centers for Disease Control and Prevention (CDC). The agency estimates that this condition affects more than 32.5 million U.S. adults. But despite being so common, there is “no cure for this disease process,” Kelly Johnson-Arbor, MD, a medical toxicology physician and co-medical director of the National Capital Poison Center, tells Best Life.

“Treatments are limited to pain control and maintenance of joint function and stability,” Johnson-Arbor explains. “NSAIDs are often used to reduce the pain and acute inflammation of arthritis.”

But over time, the study says these meds might have the opposite effect, says Leann Poston, MD, a licensed physician and medical expert for Invigor Medical. “This suggests that NSAIDS may not reduce the structural changes found in the knee joint due to osteoarthritis and may actually lead to more pain and a decrease in joint function,” Poston explains. This is due to the potential for increase inflammation. “Inflammation typically causes pain, because the swelling and buildup of tissue starts pressing against nerve endings. This pressure sends pain signals to the brain, causing discomfort,” according to Garden State Pain and Orthopedics.

Luitjens said the study was “able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint.” This indicates that the use of these pain relievers for treatment in these patients “should be revisited,” the lead researcher concluded.

But Poston, who was not involved in the study, cautioned against drawing any conclusions without more research. “This was a small study, and randomized controlled trials are needed to better advise patients about whether NSAIDs are a benefit or harmful in their case,” she says, advising patients to speak with their doctors about the best way to treat your pain.

Research contact: @bestlife

March 24, 2023

The world’s top alien hunter is about to embark on his most ambitious—and potentially, historical—mission yet, reports The Daily Beast.

Harvard physicist Avi Loeb is organizing a $1.5-million expedition to Papua New Guinea to search for fragments of a very strange meteorite that impacted just off the coast of the Pacific nation in 2014.

There is compelling evidence that the half-meter-wide meteorite, called CNEOS1 2014-01-08, traveled from outside our solar system. And that it’s made of extremely hard rock or metal—a material that’s hard and tough enough to prove the meteorite isn’t a meteorite at all. Maybe it’s an alien probe.

It’s a long-shot effort. After years of work, Loeb and his team have, with a big assist from the U.S. military, narrowed down CNEOS1 2014-01-08’s likely impact zone to a square kilometer of the ocean floor, nearly two kilometers underwater. But the fragments themselves are probably just a few millimeters in size. It’s worse than looking for a needle in a haystack. Loeb is basically preparing to look for big sand in a square-kilometer patch of small sand.

It’s worth the risk, Loeb told The Daily Beast. Any fragments the team recovers could turn out to be “technological”—that is, clearly manufactured and thus strong evidence of the existence of aliens. Or maybe they’re not artificial, but are made of some super-strong material that we’ve never observed until now. A rare metal forged in the hearts of neutron stars, for example.

In any event, “we will learn something new,” Loeb said.

The expedition is almost ready to depart for Papua New Guinea. “We have a boat,” Loeb wrote in on a post on Medium on January 27. “We have a dream team, including some of the most experienced and qualified professionals in ocean expeditions. We have complete design and manufacturing plans for the required sled, magnets, collection nets and mass spectrometer.

“And most importantly,” he wrote, “today we received the green light to go ahead,” referring to the approval of Papua New Guinea’s for the mission.

The plan, Loeb said, is to deploy a variety of custom sand-sifters—some with magnets, others like huge sieves—and methodically search the seafloor for two weeks. The main reason it’s taken eight years to organize the mission is that, first, Loeb and his team had to figure out where the meteorite’s fragments came down to Earth.

It was easier said than done, since no single instrument precisely captured CNEOS1 2014-01-08’s journey to the seafloor. But if anyone was motivated to try, it was Loeb. While these days more and more scientists are coming around to the idea that we’re probably not alone in the universe, Loeb was banging that drum even when it was unpopular.

When a very odd, shiny, football-field-size object streaked across then out of the solar system in 2017, Loeb was among the first scientists to say out loud what others may only have been thinking: This object, which scientists later named ’Oumuamua ( Hawaiian for “scout”), might be an alien probe.

And Loeb isn’t afraid to put his money—well, his donors’ money—where his mouth is. In addition to studying strange interstellar objects such as ’Oumuamua, Loeb through his Galileo Project is painstakingly building humanity’s first global network of small telescopes , which will scan the sky for alien craft, or at least the remains of alien craft.

To narrow down CNEOS1 2014-01-08’s impact zone, Loeb needed data from two sets of instruments. The first set was from U.S. military missile-warning satellites that, thanks to their sensitive infrared sensors, tend to also detect meteorites while scanning for missile-launches.

These satellites can not only provide at least a vague indication of where a meteorite is heading; they also capture images of the fireball that results from a meteorite’s fast, hot trip through Earth’s atmosphere. The timing and intensity of a fireball can tell us a lot about a meteorite’s composition. Basically, the longer it takes for the atmosphere to ignite a meteor, the tougher the meteor is.

After much wheedling, Loeb convinced the Pentagon to release the full fireball data for CNEOS1 2014-01-08. They indicated the 2014 meteorite might be the hardest meteorite on record.

The second set of data Loeb needed was much more precise telemetry for the meteorite’s path than the military could provide. So, he checked on nearby earthquake sensors. “We found that the blast wave from the meteor explosion generated a high-quality signal in a seismometer located at Manus Island,” which is part of Papua New Guinea, Loeb wrote at Medium.

Armed with the two data sets, Loeb and his team were able to narrow the likely impact zone from 100 square kilometers to just one square kilometer. “This reduction in the geographic uncertainty of the … fireball improves the search efficiency in the forthcoming ocean expedition to recover its fragments,” Loeb and company wrote in a study, not yet peer-reviewed, that appeared online on March 13.

After having arranged funding and manpower, narrowing the search zone, and getting the Papua New Guinean government’s approval, Loeb and his team are now putting the finishing touches on their special sand-sifting equipment for recovering magnetic meteoritic debris from the seafloor.

Once it’s all ready, hopefully this summer, Loeb and his team will set sail.

Expectations are running high. But Loeb said he’s bracing for disappointment. “There is a chance it will fail,” he said of his expedition. Even success could be something of a letdown, if the team recovers fragments, but those fragments turn out to be natural in origin rather than artificial.

It’s important to frame even that secondary discovery as a major advancement, Ravi Kopparapu, an astronomer at NASA’s Goddard Space Flight Center in Maryland, told The Daily Beast. “This could give us more confidence on the nature of the interstellar meteor—and could point to whether this meteor is unique or a new class of meteorites.”

Maybe Loeb and his team will go to all that trouble to find the remains of CNEOS1 2014-01-08, only to confirm it isn’t an alien probe. But don’t expect a setback like that to cause Loeb to give up his search for evidence of extraterrestrials. He said he understands how convincing the proof needs to be, and how hard it might be to find it. “Extraordinary claims require extraordinary evidence,” he said.

Research contact: @thedailybeast